abstract::Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthesised. These compou...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1890066
更新日期:2021-12-01 00:00:00
abstract::Many patients with type 2 diabetes will ultimately require the inclusion of basal insulin in their treatment regimen. Since most people with type 2 diabetes are managed in the community, it is important that primary care providers understand and correctly manage the initiation and titration of basal insulins, and help...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1925148
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The impact of acute kidney injury (AKI) on the progression of renal function in idiopathic membranous nephropathy (iMN) with nephrotic syndrome (NS) patients have not yet been reported, we sought to investigate the incidence, clinical features and prognosis of AKI in iMN with NS patients and d...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1942913
更新日期:2021-12-01 00:00:00
abstract::Background: Evidence suggests that men can play a key role in influencing maternal health behaviours, potentially affecting birthing outcomes. However, that role may not be fostered in safety net programmes like the Special Supplemental Nutrition programme for Women, Infants, and Children (WIC), a programme for which ...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1932026
更新日期:2021-12-01 00:00:00
abstract::Purpose: This metasynthesis reviews and synthesizes the existing qualitative research on adolescent well-being, with explicit attention to how context shapes girls' well-being. Well-being can be understood as a product of transactions between the individual and their context. Using qualitative research, this metasynth...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1940766
更新日期:2021-12-01 00:00:00
abstract::The birthing room is a major workplace for midwives but how it influences them in practice is not enough investigated.Purpose: This study aimed to explore midwives´ experiences of how the birthing room affects them in their work to promote a normal physiological birth.Methods: A phenomenological reflective lifeworld r...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1939937
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Verbascoside (VB), which is found in many medicinal plant families, exhibits biological activities in various diseases. However, its effects on varicocele (VCL)-induced damage remain unknown. OBJECTIVE:To investigate the effects and mechanism of VB on experimental rats with varicocele (VCL)-induced damage. MA...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1933085
更新日期:2021-12-01 00:00:00
abstract::Serine palmitoyltransferase (SPT) plays the key role on catalysing the formation of 3-ketodihydrosphingosine, which is the first step of the de novo biosynthesis of sphingolipids. SPT is linked to many diseases including fungal infection, making it a potential therapeutic target. Thus, a logical docking-based virtual ...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1915301
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Relinqing granules (RLQ) are being used alone or in combination with antibacterial drugs to treat urological disorders. OBJECTIVE:This study investigates the pharmacokinetics of RLQ in humans and the potential for RLQ-perpetrated interactions on transporters. MATERIALS AND METHODS:Twelve healthy subjects (six...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1934039
更新日期:2021-12-01 00:00:00
abstract::ABSTRACTSOur previous study first investigated feasibility of applying ultrasound (US) and microbubbles (MBs) via external auditory canal to facilitate drug delivery into inner ear. However, most drugs are in aqueous formulae and eliminated via Eustachian tubes after drug application. In this study, feasibility of sus...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1938758
更新日期:2021-12-01 00:00:00
abstract::Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind to multiple targets to ensure clinical effectiveness and reduce toxic...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1940993
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndrome (MDS) is a haematopoietic malignancy that is characterized by a heterogeneous clinical course and dysplastic maturation of blood lineages. Immune dysregulation has gained attention as one of the fundamental mechanisms responsible for the development of MDS. This study aimed to screen...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1938429
更新日期:2021-12-01 00:00:00
abstract::A retrospective study on 287 patients with SAA who underwent allo-HSCT between October 2012 and January 2020 was conducted to explore the outcomes, risk factors and treatment options for MC. Among 287 AA patients who excluded Fanconi anemia (FA), Congenital dyskeratosis (DKC), Paroxysmal nocturnal hemoglobinuria (PNH)...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1938422
更新日期:2021-12-01 00:00:00
abstract::We examined a collection of 386 animal, 451 human, and 109 archived bioaerosol samples with a new pan-species coronavirus molecular assay. Thirty-eight (4.02%) of 946 specimens yielded evidence of human or animal coronaviruses. Our findings demonstrate the utility of employing the pan-CoV RT-PCR assay in detecting var...
journal_title:One health (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1016/j.onehlt.2021.100274
更新日期:2021-12-01 00:00:00
abstract::The Covid-19 disease has recently become one of the biggest challenges globally, and there is still no specific medication. Findings showed the immune system in severe Covid-19 patients loses regulatory control of pro-inflammatory cytokines, especially IL-6 production, called the "Cytokine storm" process. This process...
journal_title:Regenerative therapypub_type: 杂志文章,评审
doi:10.1016/j.reth.2021.05.007
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Abdominal wound dehiscence (AWD) is a major complication of abdominal surgery, and neonates are a group with a high risk of AWD, which has serious consequences or can even result in death. The purpose of this study is to explore the risk factors for neonatal AWD and construct a predictive model. METHODS:The...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1938661
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The relationship between cognitive impairment (CI) and arterial stiffness in peritoneal dialysis (PD) patients has not been clearly clarified. The aim of this study was to examine the relationship between CI and arterial stiffness in PD patients. METHODS:This cross-sectional study enrolled PD patients who p...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1937221
更新日期:2021-12-01 00:00:00
abstract::The hippocampus plays a key role in memory formation and learning. According to the concept of active systems memory consolidation, transiently stored memory traces are transferred from the hippocampus into the neocortex for permanent storage. This phenomenon relies on hippocampal network oscillations, particularly sh...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1936894
更新日期:2021-12-01 00:00:00
abstract::Gestational diabetes mellitus (GDM), a common complication of pregnancy, harms the health of pregnant women and fetuses. MicroRNAs (miRNAs) dysregulation in placenta is involved in GDM. Herein, we explored the roles of miR-362-5p in GDM. After high glucose (HG) treated HTR-8/SVneo cells, CCK-8 and flow cytometry were ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1933678
更新日期:2021-12-01 00:00:00
abstract::In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. This leads to a higher proline content that exacerbates the effects of the so-called pro...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1919890
更新日期:2021-12-01 00:00:00
abstract::Objectives Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation. The aim of this study is to discover the adipocyte genes and pathways involved in obesity and type 2 diabetes using bioinformatics analysis.Methods T...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1933297
更新日期:2021-12-01 00:00:00
abstract::To determine the extent to which it is possible to provide continuity of primary care for those who visit Emergency Departments (EDs) we studied how recorded diagnoses in primary care differ, depending on whether the patient is met in an ED or a primary care office-hours practice. In the present, 12-year follow-up stu...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1935593
更新日期:2021-12-01 00:00:00
abstract::ABSTRACTThe risk of secondary infection with SARS-CoV-2 and influenza A virus is becoming a practical problem that must be addressed as the flu season merges with the COVID-19 pandemic. As SARS-CoV-2 and influenza A virus have been found in patients, understanding the in vivo characteristics of the secondary infection...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1938241
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA). METHODS:We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA. Subsequently, we perform...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1933163
更新日期:2021-12-01 00:00:00
abstract::Age-related macular degeneration (AMD) is resulted from choroidal neovascularization (CNV)-mediated cicatrization and vision loss. The sustained retinal hypoxia in retinal pigment epithelium (RPE) cells was reported to contribute to CNV. However, the underlying genetic regulatory network of hypoxia response in RPE is ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1933821
更新日期:2021-12-01 00:00:00
abstract::Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been successfully designed and synthesised. The synthesised derivatives were biologically investigated for their cytotoxic activities against HepG2 and MCF-7. Also, the tested compounds were further examined in vitro for their VEGF...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1915303
更新日期:2021-12-01 00:00:00
abstract::As gene delivery tools, lentiviral vectors (LV) have broad applications in chimeric antigen receptor therapy (CAR-T). Large-scale production of functional LV is limited by the adherent, serum-dependent nature of HEK293T cells used in the manufacturing. HEK293T adherent cells were adapted to suspension cells in a serum...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1931644
更新日期:2021-12-01 00:00:00
abstract::Hand-foot-and-mouth disease is a contagious disease common among children under 5 years old worldwide. It is caused by strains of enterovirus, especially EV-A71, which can lead to severe disease. Vaccines are the only way to fight this disease. Accordingly, it is necessary to establish an efficient and accurate method...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1934558
更新日期:2021-12-01 00:00:00
abstract::The bacterial pathogen Neisseria gonorrhoeae encodes for an α-class carbonic anhydrase (CA, EC 4.2.1.1), NgCA, which was investigated for its inhibition with a series of inorganic and organic anions. Perchlorate and hexafluorophosphate did not significantly inhibit NgCA CO2 hydrase activity, whereas the halides, azide...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1929202
更新日期:2021-12-01 00:00:00
abstract::This video-based study examines the pragmatic non-verbal comprehension skills and corresponding neural-level findings in young Finnish autistic adults, and controls. Items from the Assessment Battery of Communication (ABaCo) were chosen to evaluate the comprehension of non-verbal communication. Inter-subject correlati...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1909333
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Circular RNA microarray analysis showed hsa_circ_0010235 (circ_0010235) was highly upregulated in non-small-cell lung cancer (NSCLC) patients; however, its role in carcinogenesis and development of NSCLC cells was unrevealed. Here, we intended to investigate role and mechanism of circ_0010235 in NSCLC prolif...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1925736
更新日期:2021-12-01 00:00:00
abstract::Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell-matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA c...
journal_title:Cell adhesion & migrationpub_type: 杂志文章
doi:10.1080/19336918.2021.1924422
更新日期:2021-12-01 00:00:00
abstract::ABSTRACTAlkhurma haemorrhagic fever virus (AHFV), a tick-borne flavivirus closely related to Kyasanur Forest disease virus, is the causative agent of a severe, sometimes fatal haemorrhagic/encephalitic disease in humans. To date, there are no specific treatments or vaccines available to combat AHFV infections. A chall...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1932609
更新日期:2021-12-01 00:00:00
abstract::Circular RNA (circRNA) features prominently in the progression of hepatocellular carcinoma (HCC), of which the biological function and potential mechanism of circ_0008274 in HCC are obscure. The present study aims to explore circ_ 0008274's biological functions and underlying mechanisms in HCC. The expressions of circ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1926195
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:Peritoneal fibrosis (PF) ultimately causes ultrafiltration failure and peritoneal dialysis (PD) termination, but there are few effective therapies for it. Core fucosylation, which is catalyzed by α1,6-fucosyltransferase (Fut8) in mammals, may play a crucial role in PF development. This study aims to assess th...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1918557
更新日期:2021-12-01 00:00:00
abstract::This study aimed to develop an effective therapy against M2 macrophages and to investigate the effects of imidazole and mannose modified carboxymethyl chitosan-nanoparticles (MIC-NPs) on tumor growth and antitumor immune responses. MIC-NPs were constructed and analyzed through 1H NMR, nano-laser particle size analyzer...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1921076
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Drug interactions increase the risk of treatment failure, intoxication, hospital admissions, consultations and mortality. Computer-assisted prescription systems can help to detect interactions. OBJECTIVES:To describe the drug-drug interaction (DDI) and drug-disease interaction (DdI) prevalence identified by...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1917543
更新日期:2021-12-01 00:00:00
abstract::Peptidoglycan (PG), a heteropolysaccharide component of the mycobacterial cell wall can be shed during tuberculosis infection with immunomodulatory consequences. As such, changes in PG structure are expected to have important implications on disease progression and host responses during infection with Mycobacterium tu...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1914448
更新日期:2021-12-01 00:00:00
abstract::Ivabradine (Iva), a heart rate reducing agent that specifically inhibits the pacemaker I(f) ionic current, has been demonstrated to be cardioprotective in many cardiovascular diseases. Autophagy is an evolutionarily conserved metabolic process that regulates cardiac homeostasis. This study is aimed to explore whether ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1925008
更新日期:2021-12-01 00:00:00
abstract::Virulence plasmids of hypervirulent Klebsiella pneumoniae (hvKp) have the potential to transfer to drug-resistant strains or integrate with other plasmids, facilitating the genome evolution of threatening pathogens. We conducted an in-depth analysis of the publicly available 156 complete genome sequences of hvKp toget...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1924019
更新日期:2021-12-01 00:00:00